ISOLATION of PEPTIDOLIPIN NA DERIVATIVES from the CULTURE of NOCARDIA ARTHRITIDIS IFM10035T in the PRESENCE of MOUSE MACROPHAGE CELLS

Yasumasa Hara, Daiki Tanimura, Teruhisa Manome, Midori A. Arai, Takashi Yaguchi, Masami Ishibashi

研究成果: Article査読

抄録

We isolated two peptidolipin NA derivatives, L-Val (6) peptidolipin NA and peptidolipin NA, named as compounds 1 and 2, respectively. These compounds were produced in the co-culture extracts of Nocardia arthritidis IFM10035T and the mouse macrophage cell line J774.1, but not in the single culture of N. arthritidis. Among the two compounds along with nocarjamide (3) isolated from the co-culture of N. tenerifensis and J774.1, compounds 1 and 3 showed higher cytotoxicity against J774.1, with IC50 values of 116 μM and 25 μM, respectively. In addition, compound 1 showed a TRAIL-resistance-overcoming activity in the human gastric adenocarcinoma AGS cells.

本文言語English
ページ(範囲)185-190
ページ数6
ジャーナルHeterocycles
104
1
DOI
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 分析化学
  • 薬理学
  • 有機化学

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「ISOLATION of PEPTIDOLIPIN NA DERIVATIVES from the CULTURE of NOCARDIA ARTHRITIDIS IFM10035T in the PRESENCE of MOUSE MACROPHAGE CELLS」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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