抄録
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) potently induces apoptosis in most cancer cells, but not in normal cells, and, thus, has attracted intense interest as a promising antitumor agent. Activity-guided fractionation of the culture broth of the actinomycete CKK1172 strain led to the isolation of the antibiotic resistomycin (1) using human gastric adenocarcinoma AGS cells. Compound 1 exhibited TRAIL resistance-overcoming activity at 2 μM with 38% more inhibition than a treatment with 1 alone (without TRAIL) in TRAIL-resistant AGS cells.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 65-66 |
| ページ数 | 2 |
| ジャーナル | Natural product communications |
| 巻 | 13 |
| 号 | 1 |
| DOI | |
| 出版ステータス | Published - 2018 1月 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 薬理学
- 植物科学
- 創薬
- 補完代替医療
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
