Isolation, synthesis, and biological activity of biphenyl and m-terphenyl-type compounds from Dictyostelium cellular slime molds

Haruhisa Kikuchi, Yusuke Matsuo, Yasuhiro Katou, Yuzuru Kubohara, Yoshiteru Oshima

研究成果: Article査読

27 被引用数 (Scopus)

抄録

From the fruiting bodies of Dictyostelium polycephalum, we obtained four aromatic compounds: dictyobiphenyl A (1) and B (2) and dictyoterphenyl A (3) and B (4). The synthesis of 1-4 was performed to confirm the structures and obtain sufficient material for biological evaluation. Compound 3 was the first example of nitrogen-containing natural m-terphenyls, and the isolation of novel classes of compounds such as 3 shows that cellular slime molds are promising sources in natural product chemistry. Moreover, dictyoterphenyl A (3) showed cancer cell-selective antiproliferative activity (IC 50 2.3-8.6 μM).

本文言語English
ページ(範囲)8884-8889
ページ数6
ジャーナルTetrahedron
68
43
DOI
出版ステータスPublished - 2012 10 28
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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