Iterative direct aldol strategy for polypropionates: Enantioselective total synthesis of (-)-membrenone a and B

Kaliyamoorthy Alagiri, Shaoquan Lin, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

15 被引用数 (Scopus)

抄録

An iterative direct aldol reaction using a C3 propionate unit as an aldol donor offers expeditious access to polyketide assembly in a highly diastereo- and enantioselective manner. An all-syn polyketide array with four consecutive stereogenic centers was efficiently constructed by an aldol reaction of thiopropionamide via soft Lewis acid/hard Brønsted base cooperative catalysis. This iterative aldol strategy led to an enantioselective synthesis of (-)-membrenone A and B. (Chemical Equation Presented).

本文言語English
ページ(範囲)5301-5303
ページ数3
ジャーナルOrganic Letters
16
20
DOI
出版ステータスPublished - 2014 10 17
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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