JC virus agnoprotein colocalizes with tubulin

Shuichi Endo, Yuki Okada, Yasuko Orba, Hiroshi Nishihara, Shinya Tanaka, Kazuo Nagashima, Hirofumi Sawa

研究成果: Article

18 引用 (Scopus)

抄録

The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

元の言語English
ページ(範囲)10-14
ページ数5
ジャーナルJournal of NeuroVirology
9
発行部数SUPPL. 1
出版物ステータスPublished - 2003 6 13
外部発表Yes

Fingerprint

JC Virus
Tubulin
BK Virus
Cytoskeletal Proteins
Simian virus 40
Cell Communication
Microtubules
Open Reading Frames
Cytoplasm
Molecular Weight
Amino Acids
Antibodies

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

これを引用

Endo, S., Okada, Y., Orba, Y., Nishihara, H., Tanaka, S., Nagashima, K., & Sawa, H. (2003). JC virus agnoprotein colocalizes with tubulin. Journal of NeuroVirology, 9(SUPPL. 1), 10-14.

JC virus agnoprotein colocalizes with tubulin. / Endo, Shuichi; Okada, Yuki; Orba, Yasuko; Nishihara, Hiroshi; Tanaka, Shinya; Nagashima, Kazuo; Sawa, Hirofumi.

:: Journal of NeuroVirology, 巻 9, 番号 SUPPL. 1, 13.06.2003, p. 10-14.

研究成果: Article

Endo, S, Okada, Y, Orba, Y, Nishihara, H, Tanaka, S, Nagashima, K & Sawa, H 2003, 'JC virus agnoprotein colocalizes with tubulin', Journal of NeuroVirology, 巻. 9, 番号 SUPPL. 1, pp. 10-14.
Endo S, Okada Y, Orba Y, Nishihara H, Tanaka S, Nagashima K その他. JC virus agnoprotein colocalizes with tubulin. Journal of NeuroVirology. 2003 6 13;9(SUPPL. 1):10-14.
Endo, Shuichi ; Okada, Yuki ; Orba, Yasuko ; Nishihara, Hiroshi ; Tanaka, Shinya ; Nagashima, Kazuo ; Sawa, Hirofumi. / JC virus agnoprotein colocalizes with tubulin. :: Journal of NeuroVirology. 2003 ; 巻 9, 番号 SUPPL. 1. pp. 10-14.
@article{adcef17447234371bbc41446478a9534,
title = "JC virus agnoprotein colocalizes with tubulin",
abstract = "The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50{\%} to 60{\%} homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.",
keywords = "Agnoprotein, JC virus, Tubulin",
author = "Shuichi Endo and Yuki Okada and Yasuko Orba and Hiroshi Nishihara and Shinya Tanaka and Kazuo Nagashima and Hirofumi Sawa",
year = "2003",
month = "6",
day = "13",
language = "English",
volume = "9",
pages = "10--14",
journal = "Journal of NeuroVirology",
issn = "1355-0284",
publisher = "Springer New York",
number = "SUPPL. 1",

}

TY - JOUR

T1 - JC virus agnoprotein colocalizes with tubulin

AU - Endo, Shuichi

AU - Okada, Yuki

AU - Orba, Yasuko

AU - Nishihara, Hiroshi

AU - Tanaka, Shinya

AU - Nagashima, Kazuo

AU - Sawa, Hirofumi

PY - 2003/6/13

Y1 - 2003/6/13

N2 - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

AB - The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

KW - Agnoprotein

KW - JC virus

KW - Tubulin

UR - http://www.scopus.com/inward/record.url?scp=0038136789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038136789&partnerID=8YFLogxK

M3 - Article

C2 - 12709865

AN - SCOPUS:0038136789

VL - 9

SP - 10

EP - 14

JO - Journal of NeuroVirology

JF - Journal of NeuroVirology

SN - 1355-0284

IS - SUPPL. 1

ER -