JC virus agnoprotein colocalizes with tubulin

Shuichi Endo, Yuki Okada, Yasuko Orba, Hiroshi Nishihara, Shinya Tanaka, Kazuo Nagashima, Hirofumi Sawa

研究成果: Article

20 被引用数 (Scopus)

抄録

The human polyomavirus JC (JCV) encodes an agnoprotein that consists of 71 amino acid residues, with a molecular weight of approximately 8 kDa, from the late protein coding region. The agnoprotein of JCV shares 50% to 60% homology with those of simian virus 40 (SV40) and BK virus (BKV), and the carboxyl-terminal region of JCV agnoprotein is relatively unique. By using specific antibody to the carboxyl-terminal region of JCV agnoprotein, the authors have demonstrated that JCV agnoprotein expressed in the JCV-infected cells, where it localized predominantly in the perinuclear region of the cytoplasm, and colocalizes with the cellular cytoskeletal protein, tubulin. The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin.

本文言語English
ページ(範囲)10-14
ページ数5
ジャーナルJournal of NeuroVirology
9
SUPPL. 1
DOI
出版ステータスPublished - 2003 1 1
外部発表はい

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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