K-ras gene mutations in early colorectal cancer ... Flat elevated vs polyp-forming cancer ...

H. Hasegawa, M. Ueda, M. Watanabe, T. Teramoto, M. Mukai, M. Kitajima

研究成果: Article査読

64 被引用数 (Scopus)

抄録

K-ras gene mutations in early colorectal cancer were detected by two-step sensitive polymerase chain reaction (PCR) and enzyme digestion method. Early colorectal cancer was classified into bat elevated cancer or polyp-forming cancer according to morphology and presence of adenomatous components. A total of 60 paraffin-embedded tissue specimens from patients with early colorectal cancer were analysed. K-ras codon 12 mutations were detected in 23.3% (7/30) of flat elevated cancer and 63.3% (19/30) of polyp-forming cancer. The incidence of K-ras codon 12 mutations in flat elevated cancer was significantly lower than in polyp-forming cancer (P < 0.01). These data suggested that K-ras gene mutations may be correlated with morphology or clinical features in flat elevated cancer, and that flat elevated cancer may originate from a pathway different from adenoma-carcinoma sequence.

本文言語English
ページ(範囲)1413-1416
ページ数4
ジャーナルOncogene
10
7
出版ステータスPublished - 1995 1 1

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 癌研究

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