Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity

Tadashi Yoshida, Maho Yamashita, Chihiro Horimai, Matsuhiko Hayashi

研究成果: Article査読

43 被引用数 (Scopus)

抄録

Background: The identification of novel molecular mechanisms for cardiac hypertrophy is of considerable interest.

Results: Cardiomyocyte-specific knockout of KLF4 enhanced-adrenoreceptor agonist-induced cardiac hypertrophy by modulating myocardin expression and activity.

Conclusion: KLF4 is a novel regulator of cardiac hypertrophy.

Significance: Control of KLF4 is a potential therapeutic target for cardiac hypertrophy.

本文言語English
ページ(範囲)26107-26118
ページ数12
ジャーナルJournal of Biological Chemistry
289
38
DOI
出版ステータスPublished - 2014 9月 19

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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