Ktedonoketone and 2’-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi

Yasuhiro Igarashi, Kazuki Yamamoto, Chiaki Ueno, Nodoka Yamada, Katsuya Saito, Kazuki Takahashi, Masaru Enomoto, Shigefumi Kuwahara, Tsutomu Oikawa, Etsu Tashiro, Masaya Imoto, Ye Xiaohanyao, Tao Zhou, Enjuro Harunari, Naoya Oku

研究成果: Article

3 引用 (Scopus)

抜粋

A thermophilic bacterium Thermosporothrix hazakensis NBRC 105916 which belongs to the class Ktedonobacteria was investigated to explore its biosynthetic potential of secondary metabolites. UV-guided fractionation led to the identification of a new benzenoid metabolite designated ktedonoketone (6) and an α-diketone metabolite 2’-oxosattabacin (7) along with five known compounds. Compound 7 was previously described as a synthetic compound, but this is the first finding as a natural product. Compound 7 induced adipocyte differentiation at 10–20 μM and autophagy at 1–10 μM. Compound 6 showed weak inducing activity of adipocyte differentiation. The biosynthetic origin of hazakacin (3), an acyloin-type compound, was elucidated by 13C-labeled precursor-feeding experiments.

元の言語English
ページ(範囲)653-660
ページ数8
ジャーナルJournal of Antibiotics
72
発行部数9
DOI
出版物ステータスPublished - 2019 9 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

フィンガープリント Ktedonoketone and 2’-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Igarashi, Y., Yamamoto, K., Ueno, C., Yamada, N., Saito, K., Takahashi, K., Enomoto, M., Kuwahara, S., Oikawa, T., Tashiro, E., Imoto, M., Xiaohanyao, Y., Zhou, T., Harunari, E., & Oku, N. (2019). Ktedonoketone and 2’-oxosattabacin, benzenoid metabolites from a thermophilic bacterium Thermosporothrix hazakensis in the phylum Chloroflexi. Journal of Antibiotics, 72(9), 653-660. https://doi.org/10.1038/s41429-019-0195-7