Kurahamide, a cyclic depsipeptide analog of dolastatin 13 from a marine cyanobacterial assemblage of Lyngbya sp.

Arihiro Iwasaki, Shinpei Sumimoto, Osamu Ohno, Shoichiro Suda, Kiyotake Suenaga

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Kurahamide, a new dolastatin 13 analog, was isolated from a marine cyanobacterial assemblage, consisting mostly of Lyngbya sp. Its gross structure was elucidated by spectroscopic analysis, and the stereochemistries were assigned based on a chiral HPLC analysis of hydrolysis products. Kurahamide strongly inhibited elastase and chymotrypsin in vitro. In addition, kurahamide moderately inhibited the growth of human cancer cells, including HeLa and HL60 cells.

本文言語English
ページ(範囲)609-613
ページ数5
ジャーナルBulletin of the Chemical Society of Japan
87
5
DOI
出版ステータスPublished - 2014

ASJC Scopus subject areas

  • Chemistry(all)

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