Kyanamide, a new Ahp-containing depsipeptide from marine cyanobacterium Caldora penicillata

Kaori Ozaki, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Kyanamide (1), a new depsipeptide containing 3-amino-6-hydroxy-2-piperidone moiety, was isolated from the Caldora penicillata marine cyanobacterium collected in Okinawa. Its structure was determined by spectroscopic analysis and Marfey's analysis of acid hydrolysate. Kyanamide exhibited moderate cytotoxicity against HeLa S3 cells. 1 also exhibited potent protease inhibitory activity against elastase and chymotrypsin with IC50 values of 0.13 nM and 1.1 μM.

本文言語English
ページ(範囲)3382-3386
ページ数5
ジャーナルTetrahedron
75
25
DOI
出版ステータスPublished - 2019 6月 21

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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