La Dolce Vita of Neurexin: Synaptic Partnerships through Glycosaminoglycans

Kunimichi Suzuki, Michisuke Yuzaki

研究成果: Short survey査読

抄録

Various neurexin transcripts are thought to serve as presynaptic “hub” molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins. Various neurexin transcripts are thought to serve as presynaptic “hub” molecules by binding to their specific synaptic partners. In this issue, Zhang et al. demonstrate that neurexins are heparan sulfate (HS) proteoglycans and that the HS modification is important for synaptic function in vitro and in vivo. These findings open up the possibility of many more binding partners for the neurexins.

本文言語English
ページ(範囲)1337-1338
ページ数2
ジャーナルCell
174
6
DOI
出版ステータスPublished - 2018 9 6

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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