Lack of glycosidase inhibition by, and isolation from xanthocercis zambesiaca (leguminosae) of, 4-O-(β-D-glucopyranosyl)-fagomine [1,2,5-trideoxy-4-O-(β-D-glucopyranosyl)-1,5-imino-D-arabino-hexitol], a novel glucoside of a polyhydroxylated piperidine alkaloid

Stephen V. Evans, Alison R. Hayman, Linda E. Fellows, Tony K.M. Shing, Andrew E.Derome, George W.J. Fleet

研究成果: Article査読

55 被引用数 (Scopus)

抄録

A COSY spectrum has been used to determine the position of inter-residue linkage in 4-O-(β-D-glucopyranosyl) fagomine (1) an example of a new class of glycosides of polyhydroxylated piperidine alkaloids isolated from seed of the legume Xanthocercis zambesiaca. (Bak.) Dunn. Unlike a number of polyhydroxylated piperidines, neither the glucoside (1) nor free fagomine [1,2,5-trideoxy-1,5-imino-D-arabinohexitol] (3) showed any inhibitory activity towards glycosidase enzymes from a variety of sources.

本文言語English
ページ(範囲)1465-1468
ページ数4
ジャーナルTetrahedron Letters
26
11
DOI
出版ステータスPublished - 1985

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

フィンガープリント

「Lack of glycosidase inhibition by, and isolation from xanthocercis zambesiaca (leguminosae) of, 4-O-(β-D-glucopyranosyl)-fagomine [1,2,5-trideoxy-4-O-(β-D-glucopyranosyl)-1,5-imino-D-arabino-hexitol], a novel glucoside of a polyhydroxylated piperidine alkaloid」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル