Laminin 5 β3 and γ2 chains are frequently coexpressed in cancer cells

Shingo Akimoto, Yukihiro Nakanishi, Michiie Sakamoto, Yae Kanai, Setsuo Hirohashi

研究成果: Article

27 引用 (Scopus)

抄録

Laminin 5 plays an important role in cell migration during tumor invasion and tissue remodeling. However, previous studies have not clarified whether laminin 5 β3 chain is coexpressed with laminin 5 γ2 chain in cancer cells. The present immunohistochemical study investigated the distribution of the laminin 5 β3 and γ2 chains in 20 cases of squamous cell carcinoma of the tongue and 17 cases of colorectal carcinoma. Laminin 5 β3 and γ2 chains were expressed in the cytoplasm of tumor cells. Tumor cells at the cancer-stromal interface and at the invasive front frequently showed immunopositivity for laminin 5 β3 and γ2 chains in both squamous cell carcinoma of the tongue and colorectal carcinoma. Furthermore, strong expressions of these two proteins were observed in cancer cells invading in a scattered manner. Laminin 5 β3 expression correlated significantly with laminin 5 γ2 expression in 20 cases of squamous cell carcinoma of the tongue (P = 0.0002) and 17 cases of colorectal carcinoma (P < 0.0001). These results suggest that in squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 γ2 chain and β3 chain are both important in the invasiveness of cancer cells.

元の言語English
ページ(範囲)688-692
ページ数5
ジャーナルPathology International
54
発行部数9
DOI
出版物ステータスPublished - 2004 9

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Tongue
Neoplasms
Squamous Cell Carcinoma
Colorectal Neoplasms
kalinin
Cell Movement
Cytoplasm
Proteins

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

これを引用

Laminin 5 β3 and γ2 chains are frequently coexpressed in cancer cells. / Akimoto, Shingo; Nakanishi, Yukihiro; Sakamoto, Michiie; Kanai, Yae; Hirohashi, Setsuo.

:: Pathology International, 巻 54, 番号 9, 09.2004, p. 688-692.

研究成果: Article

Akimoto, Shingo ; Nakanishi, Yukihiro ; Sakamoto, Michiie ; Kanai, Yae ; Hirohashi, Setsuo. / Laminin 5 β3 and γ2 chains are frequently coexpressed in cancer cells. :: Pathology International. 2004 ; 巻 54, 番号 9. pp. 688-692.
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AU - Hirohashi, Setsuo

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