Laser-driven short-duration heating angioplasty: Chronic artery lumen patency and histology in porcine iliac artery

Natsumi Shimazaki, Mie Kunio, Sho Naruse, Tsunenori Arai, Masami Sakurada

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

We proposed a short-duration heating balloon angioplasty. We designed a prototype short-duration heating balloon catheter that can heat artery media to 60-70°C within 15-25 s with a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. The purpose of this study was to investigate chronic artery lumen patency as well as histological alteration of artery wall after the short-duration heating balloon dilatation with porcine healthy iliac artery. The short-term heating balloon dilated sites were angiographically patent in acute (1 hour) and in chronic phases (1 and 4 weeks). One week after the dilatation, smooth muscle cells (SMCs) density in the artery media measured from H&E-stained specimens was approx. 20% lower than that in the reference artery. One and four weeks after the dilatations, normal structure of artery adventitia was maintained without any incidence of thermal injury. Normal lamellar structure of the artery media was also maintained. We found that the localized heating restricted to artery media by the short-duration heating could maintain adventitial function and artery normal structure in chronic phase.

本文言語English
ホスト出版物のタイトルPhotonic Therapeutics and Diagnostics VIII
DOI
出版ステータスPublished - 2012
外部発表はい
イベントPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
継続期間: 2012 1月 212012 1月 24

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
8207
ISSN(印刷版)1605-7422

Other

OtherPhotonic Therapeutics and Diagnostics VIII
国/地域United States
CitySan Francisco, CA
Period12/1/2112/1/24

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

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