Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules

Kazumasa Ariyasu, Atsuhiro Ishii, Taiga Umemoto, Mitsuhiro Terakawa

研究成果: Article査読

2 被引用数 (Scopus)

抄録

The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-co-glycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release.

本文言語English
論文番号085003
ジャーナルJournal of Biomedical Optics
21
8
DOI
出版ステータスPublished - 2016 8 1

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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