Leumorphin is a potent inhibitor of vasopressin secretion.

T. Yamada, K. Nakao, H. Itoh, N. Morii, S. Shiono, M. Sakamoto, A. Sugawara, Y. Saito, G. Katsuura, M. Eigyo

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The effects of intracerebroventricular (i.c.v.) injection of leumorphin on the vasopressin secretion induced by angiotensin II or dehydration were studied in conscious unrestrained rats. The vasopressin secretion induced by angiotensin II (100 pmol) was significantly inhibited by the simultaneous injection of leumorphin (6 pmol-600 pmol) in a dose-dependent manner. In 72-hour water-deprived rats, the i.c.v. injection of leumorphin (60 pmol or 600 pmol) significantly suppressed the vasopressin secretion dose-dependently. These results suggest that leumorphin is involved in the regulation of the vasopressin secretion.

本文言語English
ページ(範囲)335-338
ページ数4
ジャーナルNIDA research monograph
75
出版ステータスPublished - 1986
外部発表はい

ASJC Scopus subject areas

  • 医学(その他)

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