Lewis Acid-catalyzed Decarboxylative Cyanation of Cyclic Enol Carbonates ®Access to Multi-substituted ¢-Ketonitriles®

Haruki Yokoyama, Yoichi Dokai, Natsuki Kimaru, Kodai Saito, Tohru Yamada

研究成果: Article査読

抄録

A Lewis acid-catalyzed decarboxylative substitution reaction of cyclic enol carbonates with a cyanation reagent was developed to give ¢-ketonitriles in good yield. It is proposed that the reaction proceeds through an oxyallyl cation intermediate or its equivalent. Interestingly, cyanation selectively took place at the more hindered site of the intermediate to afford a multi-substituted ¢-ketonitrile. This regioselectivity was observed by the cyanation of a wide range of substrates and is discussed in terms of the reaction mechanism.

本文言語English
ページ(範囲)469-472
ページ数4
ジャーナルChemistry Letters
51
4
DOI
出版ステータスPublished - 2022 4月

ASJC Scopus subject areas

  • 化学 (全般)

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