Linking structural dynamics and functional diversity in asymmetric catalysis

Akihiro Nojiri, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

116 被引用数 (Scopus)

抄録

Proteins, the functional molecules in biological systems, are sophisticated chemical devices thathave evolved over billions of years. Their function is intimately related to their three-dimensional structure and elegantly regulated by conformational changes through allosteric regulators and a number of reversible or unidirectional post-translational modifications. This functional diversification in response to external stimuli allows for an orderly and timely progression of intra- and extracellular events. In contrast, enantioselective Catalystsc generally exhibit limited conformational flexibility and thereby exert a single specific function. Exploiting the features of conformationally flexible asymmetric ligands and the variable coordination patterns of rare earth metals, we demonstrate dynamic structural and functional changes of a catalyst in asymmetric catalysis, leading to two distinct reaction outcomes in a single flask.

本文言語English
ページ(範囲)3779-3784
ページ数6
ジャーナルJournal of the American Chemical Society
131
10
DOI
出版ステータスPublished - 2009 3 18
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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