Lipopolysaccaride-induced neutrophilic inflammation in the lungs differs with age

Yoko Ito, Tomoko Betsuyaku, Yasuyuki Nasuhara, Masaharu Nishimura

研究成果: Article査読

30 被引用数 (Scopus)

抄録

In aged humans and animals, lung injuries are generally more serious and prolonged. From a kinetic perspective, the authors thus assessed whether lung expression of proinflammatory cytokines were altered with age following intratracheal lipopolysaccharide (LPS) challenge in mice. Tumor necrosis factor-α, interleukin-1β, macrophage inflammatory protein-1α, macrophage inflammatory protein-2, and keratinocyte-derived chemokine were significantly higher in 65-week-old mice along with sustained neutrophilia when compared to 11-week-old mice at 72 hours, but not at earlier time points. The authors concluded that the degree of LPS-induced neutrohilic inflammation and the expression of these cytokines differ with age at later phases of acute lung injury.

本文言語English
ページ(範囲)375-384
ページ数10
ジャーナルExperimental Lung Research
33
7
DOI
出版ステータスPublished - 2007 9

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry

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