Lipoxins A4 and B4: Comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity

A. M. Lefer, G. L. Stahl, D. J. Lefer, M. E. Brezinski, K. C. Nicolaou, C. A. Veale, Y. Abe, J. B. Smith

研究成果: Article査読

43 被引用数 (Scopus)

抄録

Lipoxins A4 (LxA4) and B4 (LxB4), two lipoxygenase-generated icosanoids of arachidonic acid metabolism, were found to have a distinct biological profile. Both LxA4 and LxB4 slowly contracted pulmonary parenchymal strips isolated from guinea pigs, rabbits, and rats in a concentration-dependent manner over the range 0.1-1 μM. This bronchoconstrictor effect was not associated with release of peptide leukotrienes or thromboxane A2, nor was it blocked by lipoxygenase inhibitors or thromboxane receptor antagonists, suggesting it is a direct effect of lipoxins. However, the leukotriene D4 (LTD4) receptor antagonist LY-171883 reduced the LxA4 response, indicating that LTD4 and LxA4 may share the same receptor. LxA4 and LxB4 also exerted an endothelium-dependent vasorelaxation in guinea pig, rat, and, to a lesser extent, rabbit aortic vascular smooth muscle. In contrast to other vasoactive icosanoids, LxA4 and LxB4 failed to aggregate rat, rabbit, or guinea pig platelets or to inhibit ADP-induced aggregation. LxA4 also enhanced the release of liver lysosomal hydrolases in a liver large granule fraction, indicating a lysosomal labilizing action of LxA4. LxA4 and LxB4 share a similar biological profile. It is not clear yet whether the lipoxins could be mediators of circulatory or pulmonary disease states.

本文言語English
ページ(範囲)8340-8344
ページ数5
ジャーナルProceedings of the National Academy of Sciences of the United States of America
85
21
DOI
出版ステータスPublished - 1988

ASJC Scopus subject areas

  • General

フィンガープリント 「Lipoxins A<sub>4</sub> and B<sub>4</sub>: Comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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