The rate of local axial gas transport in oscillatory flow through a model human central airways was measured to evaluate the gas exchange during high-frequency oscillation. A rigid model of human airways consists of asymmetrical bifurcations up to third generation, of which geometries were determined by the study of Horsfield et. al. (1971). A bolus of CO2 tracer was injected into the trachea, and effective diffusivities as a function of location in the airways were obtained by CO2 washout profiles. The rate of increase of effective diffusivity depends on the local flow conditions and differs with branches. The effective diffusivity in the left main bronchus becomes 3 times greater than that in the straight tube, whereas no significant effect is observed in the right main bronchus.
|ジャーナル||American Society of Mechanical Engineers, Bioengineering Division (Publication) BED|
|出版ステータス||Published - 1996 12月 1|
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