Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila

Hina Kosakamoto, Toshitaka Yamauchi, Yoriko Akuzawa-Tokita, Kei Nishimura, Tomoyoshi Soga, Takumi Murakami, Hiroshi Mori, Kyosuke Yamamoto, Ryo Miyazaki, Akiko Koto, Masayuki Miura, Fumiaki Obata

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Kosakamoto et al. report that wing necrosis induces dysbiotic expansion of Gluconobacter sp. in the gut, which leads to hyperactivation of innate immunity and mortality in Drosophila. This study highlights an interaction between the host and microbial factors triggering a pathological systemic inflammatory response against local necrosis.

本文言語English
論文番号107938
ジャーナルCell Reports
32
3
DOI
出版ステータスPublished - 2020 7 21

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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