Long cellular repeats flanking a defective HTLV-I provirus: Implication for site-targeted integration

S. Kubota, R. Furuta, M. Maki, H. Siomi, M. Hatanaka

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Retroviruses generally integrate as proviruses which are flanked by long-terminal repeats (LTRs) on both 5' and 3' ends. Since these LTRs are required for the efficient integration mediated by the viral integrase, it is believed that defective proviruses with a single LTR are normally formed by deletion after integration. However, we found no deletion of cellular sequences around the integration site of such a defective HTLV-1. Rather, we identified 99 bp-long direct repeats adjacent to both ends of the defective provirus. The repeated cellular sequences contained a potential poly(A) signal followed by a retroviral primer-binding-site-like sequence. The presence of the direct repeats of cellular sequences can be explained by the integration of the defective virus through homologous recombination between cellular and viral read-through sequences.

本文言語English
ページ(範囲)2873-2877
ページ数5
ジャーナルOncogene
8
10
出版ステータスPublished - 1993 1 1
外部発表はい

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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