Long-term depression (LTD) at parallel fi ber (PF) -Purkinje cell (PC) synapses is thought to play an important role in cerebellar motor learning. LTD is mediated by postsynaptic AMPA receptor endocytosis. Concurrent activation of PF and climbing fi bers generates specifi c temporal and spatial Ca 2+ dynamics in PC dendritic spines leading to activation of signaling cascade required for LTD.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)