Long-term depression at parallel fiber-Purkinje cell synapses

Kazuhisa Kouda; Wataru Kakegawa; Michisuke Yuzaki

doi:10.1007/978-3-319-24551-5_45

Long-term depression at parallel fiber-Purkinje cell synapses

Kazuhisa Kouda, Wataru Kakegawa, Michisuke Yuzaki

生理学

研究成果: Chapter

抄録

Long-term depression (LTD) at parallel fi ber (PF) -Purkinje cell (PC) synapses is thought to play an important role in cerebellar motor learning. LTD is mediated by postsynaptic AMPA receptor endocytosis. Concurrent activation of PF and climbing fi bers generates specifi c temporal and spatial Ca 2+ dynamics in PC dendritic spines leading to activation of signaling cascade required for LTD.

本文言語	English
ホスト出版物のタイトル	Essentials of Cerebellum and Cerebellar Disorders
ホスト出版物のサブタイトル	A Primer for Graduate Students
出版社	Springer International Publishing
ページ	329-334
ページ数	6
ISBN（電子版）	9783319245515
ISBN（印刷版）	9783319245492
DOI	https://doi.org/10.1007/978-3-319-24551-5_45
出版ステータス	Published - 2016 1月 1

ASJC Scopus subject areas

医学（全般）
生化学、遺伝学、分子生物学（全般）
神経科学（全般）
農業および生物科学（全般）

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10.1007/978-3-319-24551-5_45

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Long-term depression at parallel fiber-Purkinje cell synapses

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ASJC Scopus subject areas

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