Long-term effects of goshajinkigan in prevention of diabetic complications: A randomized open-labeled clinical trial

K. Watanabe, A. Shimada, K. Miyaki, A. Hirakata, K. Matsuoka, K. Omae, I. Takei

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Objective. This clinical trial was designed to investigate whether goshajinkigan reduces the onset of diabetic complications or not. Materials and Methods. A total of 332 type 2 diabetic mellitus patients were registered from 9 clinical centers from March 2000 to August 2007. Patients were randomly assigned to take goshajinkigan extract powder, 2.5 grams for 3 times a day or no kampo therapy, additionally to the regular treatment. The primary endpoints were the onset of macrovascular diseases or progression of nephropathy or retinopathy. Statistical analysis was performed by the intention-to-treat method. Results. After 5 years of observation, 116 patients were submitted to analysis. Among them, no macrovascular events were observed in both groups. Although 43 participants had upstaging of retinopathy or nephropathy in total, there was no significant difference between goshajinkigan group and control group. Deterioration of ankle reflex was suppressed in goshajinkigan group. Also glycated hemoglobin, and fasting plasma glucose were decreased in the goshajinkigan group. Conclusion. Although the power of analysis was too low to demonstrate any effects of goshajinkigan on the progression of macrovascular diseases, retinopathy or nephropathy, goshajinkigan may be beneficial for diabetic neuropathy and glycemic control.

本文言語English
論文番号128726
ジャーナルEvidence-based Complementary and Alternative Medicine
2014
DOI
出版ステータスPublished - 2014

ASJC Scopus subject areas

  • Complementary and alternative medicine

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