Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus

Masaki Kimura, Naoto Tateishi, Tomoei Shiota, Fumihiko Yoshie, Hideki Yamauchi, Masato Suzuki, Toshiaki Shibasaki

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.

本文言語English
ページ(範囲)713-716
ページ数4
ジャーナルNeuroReport
15
4
DOI
出版ステータスPublished - 2004 3月 22

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル