Long-Term Outcome of Patients with Locally Resected High- and Low-Risk Rectal Carcinoid Tumors

Kohei Shigeta, Koji Okabayashi, Hirotoshi Hasegawa, Yoshiyuki Ishii, Hiroki Ochiai, Masashi Tsuruta, Makio Mukai, Kaori Kameyama, Toshio Uraoka, Naohisa Yahagi, Yuukou Kitagawa

研究成果: Article

15 引用 (Scopus)

抄録

Background: Tumor size and lymphovascular invasion are known high-risk factors for lymph node and distant metastasis in patients with rectal carcinoid tumors. However, the optimal treatment for these tumors remains controversial. Aim: The aim of this paper is to compare the outcome of local or radical resection between patients with high-risk (tumor size >10 mm or lymphovascular invasion) disease and those with low-risk (tumor size ≤10 mm, no lymphovascular invasion) disease. Methods: Patients with rectal carcinoid tumors treated between January 1990 and March 2010 were identified retrospectively and classified into low- and high-risk groups. Results: In total, 83 patients with rectal carcinoid tumors were included, 53 (64 %) of whom were identified as low-risk and 30 (36 %) as high-risk. Local resection was performed in 50 (60 %) low-risk and 24 (29 %) high-risk patients, and postoperative recurrence was observed in one (1 %) of the high-risk patients who underwent local resection and one (11 %) who underwent radical resection. No recurrence was observed in the low-risk group. Kaplan-Meier analysis of the patients who underwent local resection revealed that the 10-year disease-free survival rate was 100 % in the low-risk group and 83.3 % in the high-risk group. Conclusions: There was no significant difference in outcome between local and radical resection.

元の言語English
ページ(範囲)768-773
ページ数6
ジャーナルJournal of Gastrointestinal Surgery
18
発行部数4
DOI
出版物ステータスPublished - 2014

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Carcinoid Tumor
Rectal Neoplasms
Neoplasms
Recurrence
Kaplan-Meier Estimate
Disease-Free Survival
Survival Rate
Lymph Nodes
Neoplasm Metastasis

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

これを引用

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title = "Long-Term Outcome of Patients with Locally Resected High- and Low-Risk Rectal Carcinoid Tumors",
abstract = "Background: Tumor size and lymphovascular invasion are known high-risk factors for lymph node and distant metastasis in patients with rectal carcinoid tumors. However, the optimal treatment for these tumors remains controversial. Aim: The aim of this paper is to compare the outcome of local or radical resection between patients with high-risk (tumor size >10 mm or lymphovascular invasion) disease and those with low-risk (tumor size ≤10 mm, no lymphovascular invasion) disease. Methods: Patients with rectal carcinoid tumors treated between January 1990 and March 2010 were identified retrospectively and classified into low- and high-risk groups. Results: In total, 83 patients with rectal carcinoid tumors were included, 53 (64 {\%}) of whom were identified as low-risk and 30 (36 {\%}) as high-risk. Local resection was performed in 50 (60 {\%}) low-risk and 24 (29 {\%}) high-risk patients, and postoperative recurrence was observed in one (1 {\%}) of the high-risk patients who underwent local resection and one (11 {\%}) who underwent radical resection. No recurrence was observed in the low-risk group. Kaplan-Meier analysis of the patients who underwent local resection revealed that the 10-year disease-free survival rate was 100 {\%} in the low-risk group and 83.3 {\%} in the high-risk group. Conclusions: There was no significant difference in outcome between local and radical resection.",
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author = "Kohei Shigeta and Koji Okabayashi and Hirotoshi Hasegawa and Yoshiyuki Ishii and Hiroki Ochiai and Masashi Tsuruta and Makio Mukai and Kaori Kameyama and Toshio Uraoka and Naohisa Yahagi and Yuukou Kitagawa",
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T1 - Long-Term Outcome of Patients with Locally Resected High- and Low-Risk Rectal Carcinoid Tumors

AU - Shigeta, Kohei

AU - Okabayashi, Koji

AU - Hasegawa, Hirotoshi

AU - Ishii, Yoshiyuki

AU - Ochiai, Hiroki

AU - Tsuruta, Masashi

AU - Mukai, Makio

AU - Kameyama, Kaori

AU - Uraoka, Toshio

AU - Yahagi, Naohisa

AU - Kitagawa, Yuukou

PY - 2014

Y1 - 2014

N2 - Background: Tumor size and lymphovascular invasion are known high-risk factors for lymph node and distant metastasis in patients with rectal carcinoid tumors. However, the optimal treatment for these tumors remains controversial. Aim: The aim of this paper is to compare the outcome of local or radical resection between patients with high-risk (tumor size >10 mm or lymphovascular invasion) disease and those with low-risk (tumor size ≤10 mm, no lymphovascular invasion) disease. Methods: Patients with rectal carcinoid tumors treated between January 1990 and March 2010 were identified retrospectively and classified into low- and high-risk groups. Results: In total, 83 patients with rectal carcinoid tumors were included, 53 (64 %) of whom were identified as low-risk and 30 (36 %) as high-risk. Local resection was performed in 50 (60 %) low-risk and 24 (29 %) high-risk patients, and postoperative recurrence was observed in one (1 %) of the high-risk patients who underwent local resection and one (11 %) who underwent radical resection. No recurrence was observed in the low-risk group. Kaplan-Meier analysis of the patients who underwent local resection revealed that the 10-year disease-free survival rate was 100 % in the low-risk group and 83.3 % in the high-risk group. Conclusions: There was no significant difference in outcome between local and radical resection.

AB - Background: Tumor size and lymphovascular invasion are known high-risk factors for lymph node and distant metastasis in patients with rectal carcinoid tumors. However, the optimal treatment for these tumors remains controversial. Aim: The aim of this paper is to compare the outcome of local or radical resection between patients with high-risk (tumor size >10 mm or lymphovascular invasion) disease and those with low-risk (tumor size ≤10 mm, no lymphovascular invasion) disease. Methods: Patients with rectal carcinoid tumors treated between January 1990 and March 2010 were identified retrospectively and classified into low- and high-risk groups. Results: In total, 83 patients with rectal carcinoid tumors were included, 53 (64 %) of whom were identified as low-risk and 30 (36 %) as high-risk. Local resection was performed in 50 (60 %) low-risk and 24 (29 %) high-risk patients, and postoperative recurrence was observed in one (1 %) of the high-risk patients who underwent local resection and one (11 %) who underwent radical resection. No recurrence was observed in the low-risk group. Kaplan-Meier analysis of the patients who underwent local resection revealed that the 10-year disease-free survival rate was 100 % in the low-risk group and 83.3 % in the high-risk group. Conclusions: There was no significant difference in outcome between local and radical resection.

KW - Local resection

KW - Rectal carcinoid tumors

KW - Survival outcome

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