Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency: Long-term outcomes of cultivated cell sheet transplantation

Jun Shimazaki, Yoshiyuki Satake, Kazunari Higa, Takefumi Yamaguchi, Hisashi Noma, Kazuo Tsubota

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Purpose: This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation (CCST), and to clarify risk factors that affected the outcomes. Methods: We retrospectively analyzed the medical charts and photographs of 246 consecutive surgeries (162 eyes from 139 patients) that used CCST for treating total limbal stem cell deficiency. Deficiency types included Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (SJS/TEN; n = 80), ocular surface burns (Burn; n = 75), ocular cicatricial pemphigoid (OCP) or pseudo-OCP (n = 58), and others (n = 33). The methods of CCST included 103 cultivated limbal epithelial transplantations (28 autologous, 62 allogeneic, and 13 living-related relatives), and 143 cultivated oral mucosal epithelial transplantations. We analyzed the rate of successful ocular surface reconstruction, clear corneas, and best-corrected visual acuity equal to or better than 20/200. Results: With a mean observation period of 357 weeks, successful ocular surface reconstruction and clear corneas at last visit were achieved in 65.1% of the patients. Corrected visual acuity equal to or better than 20/200 was achieved in 19.0% of the patients. Eyes with SJS/TEN exhibited worse outcomes compared with the Burn group. Postoperative complications included corneal ulcerations or perforations (18.3%), glaucoma (13.8%), and infections (8.5%). Multivariate analyses using the logistic mixed-effects model indicated that the presence of preoperative corneal epithelial defects was a significant risk factor for postoperative failure. Conclusions: In this series, the success rate of CCST after a mean observation period of 357 weeks was 65.1%, and preoperative epithelial defect was the most relevant risk factor.

本文言語English
ページ(範囲)663-671
ページ数9
ジャーナルOcular Surface
18
4
DOI
出版ステータスPublished - 2020 10

ASJC Scopus subject areas

  • 眼科学

フィンガープリント

「Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency: Long-term outcomes of cultivated cell sheet transplantation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル