Long-term results of amniotic membrane transplantation for partial limbal deficiency

Kenji Konomi, Yoshiyuki Satake, Shigeto Shimmura, Kazuo Tsubota, Jun Shimazaki

研究成果: Article

23 引用 (Scopus)

抄録

PURPOSE: To evaluate the long-term efficacy of amniotic membrane transplantation as a treatment option in cases with partial limbal deficiency. METHODS: Sixteen eyes of 14 patients with partial limbal deficiency underwent amniotic membrane patch (AMP) or amniotic membrane graft with patch (AMGP) following keratectomy for conjunctivalization of the cornea. The average follow-up period was 52 months. We evaluated the mean corneal epithelialization time, visual acuity improvement, complications, and recurrence rate after the surgery. RESULTS: Eleven eyes underwent AMP, and the remaining 5 eyes received AMGP. All eyes eventually attained corneal reepithelialization. The mean time to reepithelialization was not significantly different between the AMP group (9 days) and the AMGP group (27 days). At the final follow-up visit, improved Landolt visual acuity was observed in 6 of the 11 eyes in the AMP group and in 2 of the 5 eyes in the AMGP group. No intraoperative complications were observed. However, 6 eyes in the AMP group and 3 eyes in the AMGP group had a recurrence or developed a persistent epithelial defect after mean durations of 21.2 and 17.7 months, respectively. CONCLUSION: Both AMP and AMGP appear to be effective in attaining corneal reepithelialization, but neither could provide stable, clear corneal epithelialization in the long term.

元の言語English
ページ(範囲)1110-1115
ページ数6
ジャーナルCornea
32
発行部数8
DOI
出版物ステータスPublished - 2013 8

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Amnion
Transplantation
Transplants
Visual Acuity
Recurrence
Intraoperative Complications
Cornea

ASJC Scopus subject areas

  • Ophthalmology

これを引用

Long-term results of amniotic membrane transplantation for partial limbal deficiency. / Konomi, Kenji; Satake, Yoshiyuki; Shimmura, Shigeto; Tsubota, Kazuo; Shimazaki, Jun.

:: Cornea, 巻 32, 番号 8, 08.2013, p. 1110-1115.

研究成果: Article

Konomi, Kenji ; Satake, Yoshiyuki ; Shimmura, Shigeto ; Tsubota, Kazuo ; Shimazaki, Jun. / Long-term results of amniotic membrane transplantation for partial limbal deficiency. :: Cornea. 2013 ; 巻 32, 番号 8. pp. 1110-1115.
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