Long-term stability of measuring D2 receptors in schizophrenia patients treated with antipsychotics

Hiroyuki Uchida, Ariel Graff-Guerrero, Benoit H. Mulsant, Bruce G. Pollock, David C. Mamo

研究成果: Article

14 引用 (Scopus)

抄録

Background: While antipsychotic-free schizophrenia patients showed a high degree of within-subject variability in dopamine D2 receptor density over 6-24 months, no study has examined the long-term stability of D2 receptor measures in medicated patients. Methods: Four schizophrenia patients receiving a stable dose of risperidone underwent [11C]raclopride positron emission tomography scans on two occasions 5-14 months apart. Results: Plasma risperidone levels were found to be consistent between scans, and consistencies of nondisplaceable D2 binding potential and D2 occupancy were good. Conclusions: The finding supports the validity of quantification of D2 receptor binding in longitudinal PET studies of medicated patients with schizophrenia.

元の言語English
ページ(範囲)130-133
ページ数4
ジャーナルSchizophrenia Research
109
発行部数1-3
DOI
出版物ステータスPublished - 2009 4
外部発表Yes

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Antipsychotic Agents
Schizophrenia
Risperidone
Raclopride
Dopamine D2 Receptors
Positron-Emission Tomography
Longitudinal Studies

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Long-term stability of measuring D2 receptors in schizophrenia patients treated with antipsychotics. / Uchida, Hiroyuki; Graff-Guerrero, Ariel; Mulsant, Benoit H.; Pollock, Bruce G.; Mamo, David C.

:: Schizophrenia Research, 巻 109, 番号 1-3, 04.2009, p. 130-133.

研究成果: Article

Uchida, Hiroyuki ; Graff-Guerrero, Ariel ; Mulsant, Benoit H. ; Pollock, Bruce G. ; Mamo, David C. / Long-term stability of measuring D2 receptors in schizophrenia patients treated with antipsychotics. :: Schizophrenia Research. 2009 ; 巻 109, 番号 1-3. pp. 130-133.
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