Longterm effect of intermittent cyclical etidronate therapy on corticosteroid-induced osteoporosis in Japanese patients with connective tissue disease: 7-Year followup

Shinji Sato, Tetsuya Takada, Yumiko Katsuki, Noriko Kimura, Yuko Kaneko, Akira Suwa, Michito Hirakata, Masataka Kuwana

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Objective. To determine the efficacy and safety of intermittent cyclical etidronate therapy of up to 7 years for corticosteroid-induced osteoporosis. Methods. One hundred two Japanese patients who originally participated in a 3-year prospective randomized study were enrolled into an open-label followup study. All patients had received > 7.5 mg of prednisolone daily for at least 90 days before entry into the original study and were randomly assigned to 2 treatment arms: E, those receiving etidronate disodium (200 mg per day) for 2 weeks together with 3.0 g of calcium lactate and 0.75 μg of alphacalcidol daily; and C, controls receiving only the latter. Endpoints included changes from baseline in bone mineral density (BMD) of the lumbar spine and the rate of new vertebral fractures. Results. The mean (± SD) lumbar spine BMD had increased by 5.9% ± 8.8% (p = 0.00007) and 2.2% ± 5.8% (p = 0.013) from baseline after 7 years in groups E and C, respectively. This improvement in BMD in group E was significantly better than in group C (p = 0.02). The frequency of new vertebral fractures was lower in group E, resulting in reduction of the risk of such new fractures by 67% at year 7 (odds ratio 3.000; 95% confidence interval, 0.604-14.90; p = 0.18). There were no severe adverse events in group E during our study. Conclusion. Our results indicate that longterm (up to 7 years) intermittent cyclical etidronate therapy is safe and effective for prevention and treatment of corticosteroid-induced osteoporosis in patients with connective tissue diseases.

本文言語English
ページ(範囲)142-146
ページ数5
ジャーナルJournal of Rheumatology
35
1
出版ステータスPublished - 2008 1 1

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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