Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis

Sun A. Kim, Kentaro Inamura, Mai Yamauchi, Reiko Nishihara, Kosuke Mima, Yasutaka Sukawa, Tingting Li, Mika Yasunari, Teppei Morikawa, Kathryn C. Fitzgerald, Charles S. Fuchs, Kana Wu, Andrew T. Chan, Xuehong Zhang, Shuji Ogino, Zhi Rong Qian

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Background:Loss of CDH1 (E-cadherin) expression in cancer cells may promote cell migration and invasion. Therefore, we hypothesised that loss of CDH1 expression in colorectal carcinoma might be associated with aggressive features and clinical outcome.Methods:Utilising molecular pathological epidemiology database of 689 rectal and colon cancer cases in the Nurses' Health Study and the Health Professionals Follow-up Study, we assessed tumour CDH1 expression by immunohistochemistry. Multivariate logistic regression analysis was conducted to assess association of CDH1 loss with tumour growth pattern (expansile-intermediate vs infiltrative) and lymph node metastasis and distant metastasis, controlling for potential confounders including microsatellite instability, CpG island methylator phenotype, LINE-1 methylation, and PIK3CA, BRAF and KRAS mutations. Mortality according to CDH1 status was assessed using Cox proportional hazards model.Results:Loss of tumour CDH1 expression was observed in 356 cases (52%), and associated with infiltrative tumour growth pattern (odds ratio (OR), 2.02; 95% confidence interval (CI), 1.23-3.34; P=0.006) and higher pN stage (OR, 1.73; 95% CI, 1.23-2.43; P=0.001). Tumour CDH1 expression was not significantly associated with distant metastasis or prognosis.Conclusions:Loss of CDH1 expression in colorectal cancer is associated with infiltrative tumour growth pattern and lymph node metastasis.

本文言語English
ページ(範囲)199-206
ページ数8
ジャーナルBritish Journal of Cancer
114
2
DOI
出版ステータスPublished - 2016 1月 19

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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