Loss of cholinergic synapses on the spinal motor neurons of amyotrophic lateral sclerosis

Masahiro Nagao, Hidemi Misawa, Shuichi Kato, Shunsaku Hirai

研究成果: Article査読

52 被引用数 (Scopus)

抄録

The expression of vesicular acetylcholine transporter (VAChT) was examined immunohistochemically in the cholinergic synapses on the spinal motor neuron of the patient with sporadic amyotrophic lateral sclerosis (SALS). VAChT immunoreactive synapses were depleted on surviving motor neurons in SALS, while synaptophysin immunoreactivity was undiminished on the same neurons. This discrepancy suggests that in SALS, loss of cholinergic input on lower motor neurons is an early event, and may be part of the cause of death of those motor neurons.

本文言語English
ページ(範囲)329-333
ページ数5
ジャーナルJournal of Neuropathology and Experimental Neurology
57
4
DOI
出版ステータスPublished - 1998 4
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 神経学
  • 臨床神経学
  • 細胞および分子神経科学

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