抄録
We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line-derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells.
本文言語 | English |
---|---|
ページ(範囲) | 855-857 |
ページ数 | 3 |
ジャーナル | Nature Neuroscience |
巻 | 8 |
号 | 7 |
DOI | |
出版ステータス | Published - 2005 7 25 |
外部発表 | はい |
ASJC Scopus subject areas
- Neuroscience(all)