抄録
The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 1073-1078 |
| ページ数 | 6 |
| ジャーナル | International journal of oncology |
| 巻 | 12 |
| 号 | 5 |
| 出版ステータス | Published - 1998 5 |
| 外部発表 | はい |
ASJC Scopus subject areas
- Oncology
- Cancer Research