Loss of merlin-p85 protein complex in NF2-related tumors

Hideo Takeshima, Toru Nishi, Keizo Yamamoto, Takeshi Kino, Hideo Nakamura, Hideyuki Saya, Masato Kochi, Jun Ichi Kuratsu, Yukitaka Ushio

研究成果: Article

6 引用 (Scopus)


The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.

ジャーナルInternational journal of oncology
出版物ステータスPublished - 1998 5

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント Loss of merlin-p85 protein complex in NF2-related tumors' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Takeshima, H., Nishi, T., Yamamoto, K., Kino, T., Nakamura, H., Saya, H., Kochi, M., Kuratsu, J. I., & Ushio, Y. (1998). Loss of merlin-p85 protein complex in NF2-related tumors. International journal of oncology, 12(5), 1073-1078.