Loss of merlin-p85 protein complex in NF2-related tumors

Hideo Takeshima, Toru Nishi, Keizo Yamamoto, Takeshi Kino, Hideo Nakamura, Hideyuki Saya, Masato Kochi, Jun Ichi Kuratsu, Yukitaka Ushio

研究成果: Article査読

6 被引用数 (Scopus)

抄録

The NF2 tumor suppressor gene product, designated merlin, belongs to the family of molecules that links membranous protein with the cytoskeleton. We have previously shown that merlin was co-immunoprecipitated with a cellular protein, p85, in cultured cell. To analyze the alteration of merlin and associated proteins in surgical specimens, we developed a new method for biotin-labeling of whole cellular proteins. Screening of tumor tissues using our method showed that none of malignant gliomas and half of the NF2-related tumors had altered p85 and merlin. Our detection method seems useful for the screening of merlin alterations in NF2-related tumors.

本文言語English
ページ(範囲)1073-1078
ページ数6
ジャーナルInternational journal of oncology
12
5
出版ステータスPublished - 1998 5
外部発表はい

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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