Lutein and Oxidative Stress-Mediated Retinal Neurodegeneration in Diabetes

Yoko Ozawa, Mariko Sasaki

研究成果: Chapter

2 引用 (Scopus)

抜粋

Although many details remain elusive, recent progress in molecular biology has elucidated the underlying mechanisms of many disease pathogeneses, including some fundamental concepts. One such concept is that oxidative stress is involved in the age-related progression of diseases, as observed in diabetic complications and neurodegenerative diseases. Concordantly, oxidative stress accumulates with time, and can eventually overcome the biological defense systems. Therefore, the progression of the diseases might be prevented or slowed by suppressing oxidative stress. Here we focus on lutein, a plant-derived carotenoid and food factor that can act as an antioxidant in the mammalian retina. In an animal model of diabetes, the continuous intake of lutein suppresses the diabetes-related reduction of synaptophysin protein and brain-derived neurotrophic factor in the retina, and the subsequent visual function impairment. This mechanism overlaps with the renin-angiotensin system. Here we review the involvement of oxidative stress in diabetes-associated retinal neurodegeneration and discuss lutein's neuroprotective effects.

元の言語English
ホスト出版物のタイトルDiabetes
ホスト出版物のサブタイトルOxidative Stress and Dietary Antioxidants
出版者Elsevier Inc.
ページ223-229
ページ数7
ISBN(印刷物)9780124058859
DOI
出版物ステータスPublished - 2013 11 1

    フィンガープリント

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

これを引用

Ozawa, Y., & Sasaki, M. (2013). Lutein and Oxidative Stress-Mediated Retinal Neurodegeneration in Diabetes. : Diabetes: Oxidative Stress and Dietary Antioxidants (pp. 223-229). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-405885-9.00023-1