Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis

Hideto Kameda, Ayumi Okuyama, Jun Ichi Tamaru, Shinji Itoyama, Atsushi Iizuka, Tsutomu Takeuchi

研究成果: Article査読

34 被引用数 (Scopus)

抄録

We report on a patient of rheumatoid arthritis (RA) who sequentially developed an axillary mass and a fatal interstitial pneumonia during a 2-year course of methotrexate (MTX) therapy. Autopsy revealed a systemic lymph node involvement and the diagnosis of Epstein-Barr virus (EBV)-related lymphoproliferative disease (LPD) with the features of lymphomatoid granulomatosis was made. The lung tissue specimens revealed a typical diffuse alveolar damage (DAD), and small nodules consisting of atypical B lymphocytes showing positive staining for EBV were sparsely recognized only in basal lungs. This is the first report of a RA patient receiving MTX therapy sequentially developing MTX-associated lymphomatoid granulomatosis and DAD.

本文言語English
ページ(範囲)1585-1589
ページ数5
ジャーナルClinical Rheumatology
26
9
DOI
出版ステータスPublished - 2007 9 1
外部発表はい

ASJC Scopus subject areas

  • リウマチ学

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