Lysophosphatidic acid as a novel cell survival/apoptotic factor

Xiaoqin Ye, Isao Ishii, Marcy A. Kingsbury, Jerold Chun

研究成果: Review article査読

112 被引用数 (Scopus)

抄録

Lysophosphatidic acid (LPA) activates its cognate G protein-coupled receptors (GPCRs) LPA1-3 to exert diverse cellular effects, including cell survival and apoptosis. The potent survival effect of LPA on Schwann cells (SCs) is mediated through the pertussis toxin (PTX)-sensitive Gi/o/phosphoinositide 3-kinase (PI3K)/Akt signaling pathways and possibly enhanced by the activation of PTX-insensitive Rho-dependent pathways. LPA promotes survival of many other cell types mainly through PTX-sensitive Gi/o proteins. Paradoxically, LPA also induces apoptosis in certain cells, such as myeloid progenitor cells, hippocampal neurons, and PC12 cells, in which the activation of the Rho-dependent pathways and caspase cascades has been implicated. The effects of LPA on both cell survival and apoptosis underscore important roles for this lipid in normal development and pathological processes.

本文言語English
ページ(範囲)108-113
ページ数6
ジャーナルBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
1585
2-3
DOI
出版ステータスPublished - 2002 12 30

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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