Macrophage Activation by Poly(maleic acid-alt-2-cyclohexyl-1,3-dioxap-5-ene) Encapsulated in Polysaccharide-Coated Liposomes

Toshinori Sato, Kazuyuki Kojima, Taka Aki Ihda, Junzo Sunamoto, Raphael M. Ottenbrite

研究成果: Article

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An increase in the efficiency of macrophage activation has been tried by en capsulating potent polyanionic polymer immunomodulators into polysac charide-coated liposomes. For this purpose, several alternating copolymers of maleic acid (MA) and itaconic acid (IT) with 2-cyclohexyl-1,3-dioxap-5-ene (CDA), styrene (ST), and other monomers have been synthesized and frac tionated. First, the interaction between the liposomes and polyanionic polymers was investigated. As a result, poly(maleic acid-alt-2-cyclohexyl-1,3-dioxap-5-ene) (MA-CDA) was found to be the best candidate for encapsulating in the liposome while poly(itaconic acid-alt-styrene)(IA-ST) strongly perturbed these vesicles. Based on these results, MA-CDA was encapsulated in the mannan derivative- coated liposomes and the macrophage activation activity was evaluated from the superoxide production of the activated macrophages in vivo. Compared with the administration of free MA-CDA, the maximum in the superoxide pro duction appeared faster (2 h after injection) and the activity was significantly increased.

元の言語English
ページ(範囲)448-460
ページ数13
ジャーナルJournal of Bioactive and Compatible Polymers
1
発行部数4
DOI
出版物ステータスPublished - 1986 10
外部発表Yes

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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