Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.

Takanori Kanai, Koji Uraushihara, Teruji Totsuka, Akira Okazawa, Toshifumi Hibi, Shigeru Oshima, Tatsuya Miyata, Tetsuya Nakamura, Mamoru Watanabe

研究成果: Review article

19 引用 (Scopus)

抜粋

Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha, macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.

元の言語English
ページ(範囲)131-136
ページ数6
ジャーナルCurrent drug targets. Inflammation and allergy
2
発行部数2
DOI
出版物ステータスPublished - 2003 6
外部発表Yes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

フィンガープリント Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Kanai, T., Uraushihara, K., Totsuka, T., Okazawa, A., Hibi, T., Oshima, S., Miyata, T., Nakamura, T., & Watanabe, M. (2003). Macrophage-derived IL-18 targeting for the treatment of Crohn's disease. Current drug targets. Inflammation and allergy, 2(2), 131-136. https://doi.org/10.2174/1568010033484250