MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer

Keiichi Fujiya, Masanori Terashima, Keiichi Ohshima, Daisuke Aizawa, Takashi Sugino, Masakuni Serizawa, Kenichi Nakamura, Takeshi Nagashima, Keiichi Hatakeyama, Kenichi Urakami, Yasuto Akiyama, Yasuhiro Tsubosa, Yuko Kitagawa, Ken Yamaguchi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background: Resection for hepatic recurrence after gastrectomy in patients with gastric cancer may be curative; however, the prediction of hepatic recurrence remains intractable. Therefore, we aimed to explore predictive markers for hepatic recurrence in gastric and gastroesophageal junction cancer based on genetic information. Methods: This study recruited 154 patients who underwent curative gastrectomy for pathological stage II or III primary gastric and gastroesophageal junction adenocarcinoma. Genes associated with hepatic recurrence were comprehensively analyzed using whole-exome sequencing and gene expression profiling (GEP), followed by immunohistochemistry analysis for MAGEA10. The cumulative incidences of hepatic recurrence, relapse-free survival, and overall survival were evaluated. Results: A total of 12 patients with early hepatic recurrences were found within 2 years of surgery. Although there were no distinct gene mutations in recurrent patients, upregulation of MAGEA10 was identified in patients with early hepatic recurrence using GEP analysis. Immunostaining for MAGEA10 stained the cell nuclei in 29 (18.8%) of 154 samples. Furthermore, protein expression of MAGEA10 on immunohistochemistry was significantly related to a high MAGEA10 mRNA expression, high cumulative incidences of hepatic recurrence, and poor relapse-free survival. Overall survival did not differ significantly between positive and negative immunohistochemical staining for MAGEA10. The sensitivity and specificity of MAGEA10 staining for early hepatic recurrence were 58.3% and 84.5%, respectively. Conclusions: MAGEA10 represents a promising predictive marker for early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer.

本文言語English
ページ(範囲)341-351
ページ数11
ジャーナルGastric Cancer
24
2
DOI
出版ステータスPublished - 2021 3

ASJC Scopus subject areas

  • 腫瘍学
  • 消化器病学
  • 癌研究

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