Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Wakana Ohashi, Takafumi Hara, Teruhisa Takagishi, Koji Hase, Toshiyuki Fukada

研究成果: Review article査読

10 被引用数 (Scopus)

抄録

Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

本文言語English
ページ(範囲)2404-2415
ページ数12
ジャーナルDigestive Diseases and Sciences
64
9
DOI
出版ステータスPublished - 2019 9月 15

ASJC Scopus subject areas

  • 生理学
  • 消化器病学

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