Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

Wakana Ohashi, Takafumi Hara, Teruhisa Takagishi, Kouji Hase, Toshiyuki Fukada

研究成果: Review article

4 被引用数 (Scopus)


Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

ジャーナルDigestive Diseases and Sciences
出版ステータスPublished - 2019 1 1

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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