Maintenance of tight junction barrier integrity in cell turnover and skin diseases

Mariko Yokouchi, Akiharu Kubo

研究成果: Review article

6 引用 (Scopus)

抄録

The skin forms a life-sustaining barrier between the organism and the physical environment. The physical barrier of the skin is mainly comprised of the stratum corneum (SC) and tight junctions (TJs). In recent years, there have been significant advances in our understanding of the epidermal TJ function, composition and regulation. In contrast to the SC, TJs are highly dynamic structures. It was discovered that spatiotemporal regulation of dynamic TJ replacement from cell to cell maintains the TJ barrier homeostasis of the skin, despite continuous cellular turnover. This review summarizes current knowledge about how TJ barrier homeostasis is maintained in simple and stratified epithelia, and how diseases and other conditions affect the TJ barrier in the skin.

元の言語English
ページ(範囲)876-883
ページ数8
ジャーナルExperimental Dermatology
27
発行部数8
DOI
出版物ステータスPublished - 2018 8 1

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Tight Junctions
Skin Diseases
Skin
Maintenance
Cornea
Homeostasis
Architectural Accessibility
Chemical analysis
Epithelium

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

これを引用

Maintenance of tight junction barrier integrity in cell turnover and skin diseases. / Yokouchi, Mariko; Kubo, Akiharu.

:: Experimental Dermatology, 巻 27, 番号 8, 01.08.2018, p. 876-883.

研究成果: Review article

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