Maintenance of tight junction barrier integrity in cell turnover and skin diseases

Mariko Yokouchi, Akiharu Kubo

研究成果: Review article査読

24 被引用数 (Scopus)

抄録

The skin forms a life-sustaining barrier between the organism and the physical environment. The physical barrier of the skin is mainly comprised of the stratum corneum (SC) and tight junctions (TJs). In recent years, there have been significant advances in our understanding of the epidermal TJ function, composition and regulation. In contrast to the SC, TJs are highly dynamic structures. It was discovered that spatiotemporal regulation of dynamic TJ replacement from cell to cell maintains the TJ barrier homeostasis of the skin, despite continuous cellular turnover. This review summarizes current knowledge about how TJ barrier homeostasis is maintained in simple and stratified epithelia, and how diseases and other conditions affect the TJ barrier in the skin.

本文言語English
ページ(範囲)876-883
ページ数8
ジャーナルExperimental Dermatology
27
8
DOI
出版ステータスPublished - 2018 8月

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学

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