Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists

Ayako Ohnishi, Hisakazu Ohtani, Yasufumi Sawada

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Aim: To evaluate quantitatively the influence of bioavailability and plasma unbound fraction (fu) on the extent of interaction between grapefruit juice (GFJ) and calcium antagonists. Methods: The extent of drug-GFJ interaction was evaluated from reported clinical interaction studies of 11 calcium antagonists. The relationship between extent of interaction and bioavailability or fu was analysed. Results: The following significant hyperbolic relationships were observed: [Extent] = 12.2/[bioavailability] + 1 and [Extent] = 0.718/[fu ] + 1. Conclusions: Bioavailability and fu are major determinant factors of calcium antagonist-GFJ interaction: a drug with smaller bioavailability or lower fu is likely to exhibit a more potent interaction, and vice versa.

本文言語English
ページ(範囲)196-199
ページ数4
ジャーナルBritish journal of clinical pharmacology
62
2
DOI
出版ステータスPublished - 2006 8
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)

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