Manoalide derivatives from a marine sponge Luffariella sp. collected in Palau

Michio Namikoshi, Shigeo Suzuki, Shiori Meguro, Hiroshi Nagai, Yoshio Koike, Akira Kitazawa, Hisayoshi Kobayashi, Taiko Oda, Junko Yamada

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Two diastereomers of 24-O-methylmanoalide (1 and 2) and (6Z)-neomanoalide-24,25-diacetate (3) were isolated together with manoalide (4), seco-manoalide (5), (4E,6E)-dehydromanoalide (6) and manoalide-25-acetate (7) from a marine sponge Luffariella sp. collected in Palau. Two methyl ethers of manoalide (1 and 2) were revealed to be derived from manoalide, the main component of the extract, during the separation procedure. The stereochemistries of 1 (24R) and 2 (24S) were assigned based on the NOESY data for 2 and two 24,25-di-O-methylmanoalides (8 and 9), synthesized from 1 and 2. Although 3 has been chemically transformed from (6Z)-neomanoalide, this is the first report of the isolation of this compound from a marine sponge. Compounds 1, 2, 4, 5 and 7 showed an antibacterial activity against Staphylococcus aureus at 5-10 μg, while 3, 8 and 9 were not active at 50 μg.

本文言語English
ページ(範囲)152-158
ページ数7
ジャーナルFisheries Science
70
1
DOI
出版ステータスPublished - 2004 2月 1

ASJC Scopus subject areas

  • 水圏科学

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