Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin

M. Shimizu, S. Shiota, T. Mizushima, H. Ito, T. Hatano, T. Yoshida, T. Tsuchiya

研究成果: Article査読

101 被引用数 (Scopus)

抄録

We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of β-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various β-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.

本文言語English
ページ(範囲)3198-3201
ページ数4
ジャーナルAntimicrobial Agents and Chemotherapy
45
11
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

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