Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice

Nobuyuki Sakayori, Masanori Katakura, Kei Hamazaki, Oki Higuchi, Kazuki Fujii, Ryoji Fukabori, Yoshio Iguchi, Susumu Setogawa, Keizo Takao, Teruo Miyazawa, Makoto Arita, Kazuto Kobayashi

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The increasing prevalence of obesity and its effects on our society warrant intensifying basic animal research for understanding why habitual intake of highly palatable foods has increased due to recent global environmental changes. Here, we report that pregnant mice that consume a diet high in omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and low in omega-3 (n-3) PUFAs (an n-6high/n-3low diet), whose n-6/n-3 ratio is approximately 120, induces hedonic consumption in the offspring by upregulating the midbrain dopaminergic system. We found that exposure to the n-6high/n-3low diet specifically increases the consumption of palatable foods via increased mesolimbic dopamine release. In addition, neurodevelopmental analyses revealed that this induced hedonic consumption is programmed during embryogenesis, as dopaminergic neurogenesis is increased during in utero access to the n-6high/n-3low diet. Our findings reveal that maternal consumption of PUFAs can have long-lasting effects on the offspring’s pattern for consuming highly palatable foods.

本文言語English
論文番号473
ジャーナルCommunications biology
3
1
DOI
出版ステータスPublished - 2020 12 1

ASJC Scopus subject areas

  • 医学(その他)
  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)

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