Matrix metalloproteinase inhibitor, marimastat, decreases peritoneal spread of gastric carcinoma in nude mice

Masaru Kimata, Yoshihide Otani, Tetsuro Kubota, Naoki Igarashi, Takeyoshi Yokoyama, Norihito Wada, Nobunari Yoshimizu, Masato Fujii, Kaori Kameyama, Yasunori Okada, Koichiro Kumai, Masaki Kitajima

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Marimastat, a matrix metalloproteinese inhibitor, was examined for the ability to prevent peritoneal dissemination of a human gastric cancer xenograft, TMK-1. Even with novel approaches such as molecular targeting of cancer chemotherapy, peritoneal dissemination of gastric cancer has little sensitivity to anticancer drugs, and it is impossible to inhibit its growth completely. Intraperitoneal injection of TMK-1 into nude mice at 5 × 105 cells/body resulted in carcinomatous peritonitis that mimicked clinical cases. Continuous administration of marimastat (18 mg/kg/day) from 24 h after the tumor inoculation successfully inhibited the growth of peritoneal dissemination nodules. Combined administration of marimastat (18 mg/kg/day) and mitomycin C (MMC, 2 mg/kg) showed synergistic inhibition of growth of peritoneal dissemination, being superior to MMC alone (2 mg/kg). Although marimastat alone could not increase survival time with statistical significance, combined administration of marimastat and MMC had a survival benefit with statistical significance. The combination of marimastat and MMC increased the preventive effect on peritoneal dissemination. Marimastat seems to be a candidate for the prevention of peritoneal spread of gastric carcinoma.

本文言語English
ページ(範囲)834-841
ページ数8
ジャーナルJapanese Journal of Cancer Research
93
7
DOI
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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