Maximum tumor diameter is a simple and valuable index associated with the local extent of disease in clinically localized prostate cancer

Ryuichi Mizuno, Jun Nakashima, Makio Mukai, Hajime Ookita, Ken Nakagawa, Mototsugu Oya, Takashi Ohigashi, Ken Marumo, Masaru Murai

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Background: The present study was undertaken to investigate the association of pathological features, including the total tumor volume (TTV), maximum tumor area (MTA), and maximum tumor diameter (MTD), with the local extent of disease in clinically localized prostate cancer. Methods: Serial whole sections of the prostate from 164 patients who underwent radical prostatectomy for localized prostate cancer were investigated. The correlations between the indicators of tumor size, including the TTV, MTA, and MTD, and other pathological parameters were evaluated. Results: The MTD, MTA, and TTV were significantly correlated with each other. Multivariate stepwise logistic regression analysis indicated that the Gleason score, perineural invasion, microvascular invasion, and MTD were significant independent parameters associated with extraprostatic disease. Conclusion: The histological tumor grade, perineural invasion, microvascular invasion, and tumor size were correlated with the local extent of disease. The MTD, a simple, easy, and inexpensive parameter, is a more significant pathological feature associated with the local extent of disease than the MTA or TTV.

本文言語English
ページ(範囲)951-955
ページ数5
ジャーナルInternational Journal of Urology
13
7
DOI
出版ステータスPublished - 2006 7

ASJC Scopus subject areas

  • 泌尿器学

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