TY - JOUR
T1 - MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes
AU - Yuasa, Sachiko
AU - Maruyama, Taro
AU - Yamamoto, Yukihiro
AU - Hirose, Hiroshi
AU - Kawai, Toshihide
AU - Matsunaga-Irie, Seiko
AU - Itoh, Hiroshi
N1 - Funding Information:
This research was partially supported by research grants from the Ministry of Education, Science, Sports and Culture, Japan. We are grateful to A. Shimada for his thoughtful advice and discussion.
PY - 2009/12
Y1 - 2009/12
N2 - Aims: Cardiovascular diseases are the major cause of mortality in patients with diabetes mellitus. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine and plays an important role in cardiovascular diseases. The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes. Methods: The subjects were 303 unrelated patients who were diagnosed with type 2 diabetes mellitus. To evaluate macroangiopathy, we measured carotid artery intima-media thickness (IMT) by ultrasonography. The MCP-1 A-2518G polymorphism was determined by TaqMan PCR method. Results: IMT in patients with the MCP-1 -2518 AG or GG genotype was significantly greater than the AA-genotype (P = 0.007). Simple regression analysis showed that age, systolic blood pressure, LDL-cholesterol, the MCP-1 -2518 AG + GG polymorphism, and HbA1c level were correlated with IMT (P < 0.0001, <0.0001, 0.006, 0.007, 0.025, respectively). In multiple regression analysis, the MCP-1 -2518 AG + GG polymorphism was the third strongest independent determinant of IMT in patients with type 2 diabetes (P = 0.021), subsequent to age and systolic blood pressure. Conclusion: Assessment of the MCP-1 A-2518G polymorphism would be useful in identifying the risk of developing carotid atherosclerosis in patients with type 2 diabetes.
AB - Aims: Cardiovascular diseases are the major cause of mortality in patients with diabetes mellitus. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine and plays an important role in cardiovascular diseases. The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes. Methods: The subjects were 303 unrelated patients who were diagnosed with type 2 diabetes mellitus. To evaluate macroangiopathy, we measured carotid artery intima-media thickness (IMT) by ultrasonography. The MCP-1 A-2518G polymorphism was determined by TaqMan PCR method. Results: IMT in patients with the MCP-1 -2518 AG or GG genotype was significantly greater than the AA-genotype (P = 0.007). Simple regression analysis showed that age, systolic blood pressure, LDL-cholesterol, the MCP-1 -2518 AG + GG polymorphism, and HbA1c level were correlated with IMT (P < 0.0001, <0.0001, 0.006, 0.007, 0.025, respectively). In multiple regression analysis, the MCP-1 -2518 AG + GG polymorphism was the third strongest independent determinant of IMT in patients with type 2 diabetes (P = 0.021), subsequent to age and systolic blood pressure. Conclusion: Assessment of the MCP-1 A-2518G polymorphism would be useful in identifying the risk of developing carotid atherosclerosis in patients with type 2 diabetes.
KW - Atherosclerosis
KW - Intima-media thickness (IMT)
KW - MCP-1
KW - SNP
KW - Type 2 diabetes
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U2 - 10.1016/j.diabres.2009.09.001
DO - 10.1016/j.diabres.2009.09.001
M3 - Article
C2 - 19781803
AN - SCOPUS:70350618783
SN - 0168-8227
VL - 86
SP - 193
EP - 198
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -
